Title: RETINOPATHY TREATMENT OF THE PREMATURE WITH TOPICAL

Ketorolac topic. A therapeutic possibility in the Retinopaty of Prematurity? Retrospective Title: cohort study Summary: Objective: Evaluate if the topical ketorolac diminishes the progression of Retinopathy of the Premature one (ROP) to severe stages that have an impact on the visual capacity of the child. Methods: Research of retrospective cohort, design before-and-after. Comparing the need for cryotherapy for ROP between the groups of preterm newborns less than 1250 g. or 30 weeks of gestational age (eg) that had high-risk ophthalmological signs to develop ROP or initial ROP and that were dealt with topical ketorolac during the years 2001 and 2001 and the preterm children of similar characteristics entered the HUMN of Córdoba, Argentina during 1999 and 2000, without that treatment. Results: Forty-three children received treatment and 35 children were in the control group. Of the children who received treatment 1 (2.3%) form developed threshold of ROP and cryotherapy received. In the control group 6 (17%) needed cryotherapy, the difference of express incidence: OR= 0.12, interval of confidence of 95%= 0 to 0.85 (P = 0,041). Adverse effects attributable to the ketorolac were not registered. Conclusion: the use of ketorolac in ophthalmic drops diminished the incidence severely of ROP and the requirements of retinal ablation. It seems to be well tolerated by the children preterm and it would not interfere with its systemic balance. This first experience with topical aines to only diminish the progression of ROP points out the possibility of developing a new therapeutic tool in this devastating disorder, and requires the realization of Random clinical research to demonstrate its efficacy and safety.